Topical erythromycin and clindamycin are generally well-tolerated and have been shown to reduce inflammatory lesions by 46% to 70% in several randomized controlled trials.2 Monotherapy with topical antibiotics should not be used routinely beause P. acnes may become resistant within one month after daily treatment has begun.6 Some argue that this resistance is not relevant because the antibiotics (e.g., clindamycin, tetracyclines, erythromycin) also have intrinsic anti-inflammatory and antimicrobial effects.11 However, antibiotic-resistant Staphylococcus epidermidis and Staphylococcus aureus may also develop with monotherapy; resistance can be avoided when a topical antibiotic is combined with benzoyl peroxide.12
Never ever ever use proactiv it is horrible it bleaches ur face and makes it whiter and whiter! I recommend Mary Kay with all natural ingredients and when I used proactiv it worked for me but I learned proactiv Is a horrible way to try and get rid of acne/pimples/blemishes
What it does: It is thought to help unplug follicles and keep pores clear. It also increases the speed at which surface skin cells are replaced and helps reduce inflammation. A study done on Retin-A Micro, a particular brand of tretinoin, showed a 32-45% reduction in total “lesions.”2
I would not use toothpaste either. It would burn the skin and I heard darken the zit. I used a pill called Wipeout from stop acne fast that worked. it took some time but it worked real well. I also showered three times a day and changed my pillowcases every two days.
Isotretinoin is a teratogen, so pregnancy must be avoided. Contraception counseling is mandatory, and two negative pregnancy test results are required prior to the initiation of therapy in women of childbearing potential. The baseline laboratory examination should also include cholesterol and triglyceride assessment, hepatic transaminase levels, and a CBC count. Pregnancy tests and a lipid panel and liver enzyme examination should be repeated monthly during treatment while dosing is changing. Once a level dose is used and the lipids, liver enzymes, and CBC count are normal, these tests may be discontinued.  Other adverse effects include dry skin, lips, and eyes; muscle aches; and headaches. Patients experiencing severe headaches, decreased night vision, or adverse psychiatric events should stop taking isotretinoin immediately. 
At each appointment, after I saw my doctor and she reviewed my blood work, she would submit her portion of iPledge. Once my pharmacy received the information, usually within a few hours, I could finally pick up my prescription—so long as it was done within a seven-day window of the pregnancy test. Thirty days later, I’d repeat the entire process.
As common as acne is, it remains a skin disease that is imperfectly understood. Some forms are incurable, some can be cured, and most simply go away Sulfur their own. Exactly what can cause it to develop is often a mystery. What are known are those things that most often can contribute to an outbreak of the disease. Most explanations for the appearance of the disease center on clogging of the skin pores. The clogging of a pore usually involves dead skin cells. Normally, these dead cells will rise to the top of the pore where they are then shed. What can sometimes happen however is that sebum, the oil that lubricates the skin, can cause these dead skin cells to stick together and become trapped within the pore.
Topical (externally applied) antibiotics and antibacterials: These include erythromycin (E-Mycin, Eryc, Ery-Tab, PCE, Pediazole, Ilosone), clindamycin (BenzaClin, Duac), sulfacetamide (Klaron), and azelaic acid (Azelex or Finacea).
Acne treatment that works throughout the body: Medicine that works throughout the body may be necessary when you have red, swollen types of acne. This type of treatment is usually necessary to treat acne cysts and nodules. Your dermatologist may prescribe one or more of these:
Use a sheet or face mask. Sheet or Face masks contain compounds that soothe your skin and kill bacteria. Use a sheet or face mask 2-3 times a week for 15-20 minutes to dry out your skin and clean out your pores. Buy face masks from your local beauty supply or drugstore, or make your own at home.
Erythromycin and azithromycin are second-line therapies called macrolides. Azithromycin is dosed 3 times per week to 4 times per month to treat acne. Macrolides can cause GI upset and, in severe cases, cardiac conduction abnormalities and even hepatotoxicity.